Description

Regenerative Potential and Cellular Longevity

Originally discovered by Russian scientists, Epithalon is a tetrapeptide extensively studied in the context of healthy aging, longevity, sleep regulation, and immune system support.

This peptide primarily works by activating telomerase, an enzyme responsible for maintaining and extending telomeres—the protective caps at the ends of chromosomes. Telomere preservation is directly linked to the maintenance of healthy cellular function and reduced signs of premature aging.

Key Potential Benefits Observed in Research

Cellular Longevity

Research suggests Epithalon may extend the lifespan of model organisms, with reductions of up to 52% in mortality rates in flies and rats, and up to 27% life extension in mice prone to chronic disease.

Antioxidant Activity

By reducing oxidative stress, Epithalon supports tissue protection and enhances the cellular response to environmental damage.

DNA and Gene Regulation

This peptide has shown the ability to positively influence the expression of genes related to immune function, cellular repair, and extracellular matrix maintenance, while reducing replication errors and supporting genomic integrity.

Skin Health

Studies suggest Epithalon activates genes related to collagen production and skin regeneration, contributing to improved firmness, elasticity, and cellular protection.

Oncology Research

Experimental models show that Epithalon may help inhibit the growth of certain tumors and modulate genes involved in cancer therapy response, such as the PER1 gene, potentially enhancing treatments like radiation therapy.

Melatonin Regulation

This peptide has also demonstrated a positive effect on the body’s natural production of melatonin, essential for sleep quality, immune balance, and hormonal regulation—particularly in aging populations.

Eye Health Support

Preliminary research indicates structural and functional improvements in degenerative retinal diseases, such as retinitis pigmentosa.

Application in Research and Longevity Science

Thanks to its unique profile, Epithalon has gained attention among scientists, functional medicine practitioners, and biohackers in the United States as a promising agent in the field of biogerontology. It is studied in various experimental protocols targeting cellular regeneration and lifespan extension.

Note: All information provided is for educational purposes only. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult with a licensed professional for proper handling and usage guidelines.

Referenced Citations

V. N. Anisimov, S. V. Mylnikov, and V. K. Khavinson, “Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats,” Mech. Ageing Dev., vol. 103, no. 2, pp. 123–132, Jun. 1998. [PubMed]
V. K. Khavinson, I. E. Bondarev, and A. A. Butyugov, “Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells,” Bull. Exp. Biol. Med., vol. 135, no. 6, pp. 590–592, Jun. 2003. [PubMed]
T. A. Dzhokhadze, T. Z. Buadze, M. N. Gaiozishvili, M. A. Rogava, and T. A. Lazhava, “[Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)],” Georgian Med. News, no. 225, pp. 94–97, Dec. 2013. [PubMed]
V. N. Anisimov et al., “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice,” Biogerontology, vol. 4, no. 4, pp. 193–202, 2003. [PubMed]
V. K. Khavinson, S. I. Tarnovskaya, N. S. Linkova, V. E. Pronyaeva, L. K. Shataeva, and P. P. Yakutseni, “Short cell-penetrating peptides: a model of interactions with gene promoter sites,” Bull. Exp. Biol. Med., vol. 154, no. 3, pp. 403–410, Jan. 2013. [PubMed]
N. S. Lin’kova, B. I. Kuznik, and V. K. Khavinson, “[Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging],” Adv. Gerontol. Uspekhi Gerontol., vol. 25, no. 3, pp. 478–482, 2012. [PubMed]
N. I. Chalisova, N. S. Lin’kova, A. N. Zhekalov, A. O. Orlova, G. A. Ryzhak, and V. K. Khavinson, “[Short peptides stimulate skin cell regeneration during ageing],” Adv. Gerontol. Uspekhi Gerontol., vol. 27, no. 4, pp. 699–703, 2014. [PubMed]
N. S. Lin’kova et al., “Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro,” Bull. Exp. Biol. Med., vol. 161, no. 1, pp. 175–178, May 2016. [PubMed]
I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinski, A. V. Semenchenko, V. K. Khavinson, and V. N. Anisimov, “Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes,” Bull. Exp. Biol. Med., vol. 144, no. 6, pp. 825–830, Dec. 2007. [PubMed]
G. Kossoy, V. N. Anisimov, H. Ben-Hur, N. Kossoy, and I. Zusman, “Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice,” Vivo Athens Greece, vol. 20, no. 2, pp. 253–257, Apr. 2006. [PubMed]
V. N. Anisimov et al., “Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice,” Int. J. Cancer, vol. 101, no. 1, pp. 7–10, 2002. [PubMed]
V. N. Anisimov, V. K. Khavinson, I. N. Alimova, A. V. Semchenko, and A. I. Yashin, “Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice,” Bull. Exp. Biol. Med., vol. 134, no. 2, pp. 187–190, Aug. 2002. [PubMed]
I. A. Vinogradova, A. V. Bukalev, M. A. Zabezhinski, A. V. Semenchenko, V. K. Khavinson, and V. N. Anisimov, “Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens,” Bull. Exp. Biol. Med., vol. 145, no. 4, pp. 472–477, Apr. 2008. [PubMed]
S. Gery, N. Komatsu, L. Baldjyan, A. Yu, D. Koo, and H. P. Koeffler, “The circadian gene per1 plays an important role in cell growth and DNA